FACTS ABOUT NAD+ AND ITS ROLE IN MITOCHONDRIAL FUNCTION REVEALED

7c,d). Inhibition of glycolysis altered neither replication fork development nor the effects of NAD+ treatment, suggesting that glycolysis just isn't a limiting variable for NAD+-induced effects on DNA synthesis. Phenocopying the effect of BPTES, oligomycin rescued the inhibitory effect of NAD+ treatment on fork speed partially in HeLa and entirely